“The objective of the clinical case below is to describe the surgical approach of a reconstructive therapy to treat an intrabony peri-implant defect, using a collagenated xenograft, resorbable collagen membrane and EMD after a peri-implant surface debridement with a chitosan brush. This clinical case is part of an ongoing randomized controlled clinical trial. This study aims to compare the clinical benefit of the adjunctive use of enamel matrix derivative in combination with a xenograft and a collagen membrane in the reconstructive therapy of peri-implant-related intrabony defects.”